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Do you have a folder with more than 100,000 items inside of it?
(files, other folders, shortcuts, etc.)

In SharePoint, once a folder contains 100,000 or more items, the folder permissions cannot be modified. This means that individual access cannot be granted nor removed from the folder until it contains fewer than 100,000 items.

We recommend pre-staging large folders' permissions using a SharePoint Group prior to your final migration, so access can be added/removed via Group membership, even when the permissions of the folder itself cannot be modified.

You may also remove sub-folders from the folder in question until the count is below 100,000 and thus allows you to modify permissions.To have alter access while the folder has more than 100,000 items, you must use User Groups. Learn more: Manage Folder Permissions in SharePoint using User Groups

Do you have a large number of files in an historical, or archival, status (300,000 or more)?

(Records that you are keeping but do not access frequently)

You may want to have this data reside on a discrete SharePoint site.

If you have many thousands of files that you do not access regularly, placing them in a separate site will speed up operations on your primary site if you do not synchronize this secondary, archival, site with your computer.